The Mike DeStefano documentary, titled Drugs. Disease. Death. A Comedy with Mike DeStefano, is a long-awaited tribute to the late stand-up comedian (1966–2011), featuring reflections from peers like Marc Maron, Colin Quinn, Conan O'Brien, Eugene Mirman, Roy Wood Jr., and others. The film chronicles DeStefano's raw, fearless life and career—from his early heroin addiction starting at age 12, his recovery journey, his work as a drug counselor, the heartbreaking loss of his wife to AIDS, to his brutally honest, profanity-laced comedy that turned personal tragedy into dark, cathartic humor.

​

Join us as we embark on a time capsule that takes us through several decades of adversity through Mike's amazing ability of storytelling. Through multiple interviews, recordings of his one-man show, and appearances as a stand-up on Comedy Central and his contributions to The Moth series, Mike navigates us through some of the most difficult and controversial periods of the last 50 years.

​

Mike was a recovery community pillar and one of the most authentic voices in comedy who earned deep respect from his peers before his sudden death from a heart attack in 2011. Drugs. Disease. Death. A Comedy aims to preserve and amplify its legacy, reminding audiences of the profound, often overlooked power of "recovery comedy" in confronting life's darkest chapters with savage wit and unflinching truth.